Ontology highlight
ABSTRACT:
SUBMITTER: Petravic J
PROVIDER: S-EPMC2994900 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Petravic Janka J Davenport Miles P MP
PloS one 20101130 11
Many studies have shown that vaccines inducing CD8+ T cell responses can reduce viral loads and preserve CD4+ T cell numbers in monkey models of HIV infection. The mechanism of viral control by the vaccine-induced CD8+ T cells is usually assumed to be cytolysis of infected cells. However, in addition to cytolysis of infected cells, CD8+ T cells secrete a range of soluble factors that suppress viral replication. We have studied the dynamics of virus and CD4+ T cells in a successful vaccination-ch ...[more]