Ontology highlight
ABSTRACT:
SUBMITTER: Han L
PROVIDER: S-EPMC2995042 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20100725 21
Human Silent Information Regulator Type 1 (SIRT1) is an NAD(+)-dependent deacetylase protein which is an intermediary of cellular metabolism in gene silencing and aging. SIRT1 has been extensively investigated and shown to delay senescence; however, less is known about the regulation of SIRT1 during aging. In this study, we show that the peroxisome proliferator-activated receptor-γ (PPARγ), which is a ligand-regulated modular nuclear receptor that governs adipocyte differentiation and inhibits c ...[more]