Ontology highlight
ABSTRACT:
SUBMITTER: Goldbach-Mansky R
PROVIDER: S-EPMC2995268 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Goldbach-Mansky Raphaela R Kastner Daniel L DL
The Journal of allergy and clinical immunology 20091201 6
The discovery of the genetic causes of a rare group of immune-mediated inflammatory conditions that mimic infections and allergic conditions in their clinical presentation and the molecular understanding of the function of the mutated molecules in these diseases has led to a revolution in our understanding of the pathogenesis of systemic and local inflammation. The proteins mutated in a number of these so-called autoinflammatory diseases are part of, or regulate the activity of, intracellular mo ...[more]