Ontology highlight
ABSTRACT:
SUBMITTER: Chinnadurai R
PROVIDER: S-EPMC2995273 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Chinnadurai Raghavan R Grakoui Arash A
Hepatology (Baltimore, Md.) 20101109 6
<h4>Unlabelled</h4>Liver fibrosis is mediated by the transformation of hepatic stellate cells (HSC) from a quiescent to an activated state. To understand the role of HSC in liver immunity, we investigated the effect of this transition on T cell stimulation in vitro. Unlike quiescent HSC, activated HSC did not induce proliferation of antigen-specific T cells. Phenotypic analysis of quiescent and activated HSC revealed that activated HSC expressed the coinhibitory molecule B7-H4. Silencing B7-H4 b ...[more]