Ontology highlight
ABSTRACT:
SUBMITTER: Cui G
PROVIDER: S-EPMC2995291 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cui Gaofeng G Benirschke Robert C RC Tuan Han-Fang HF Juranić Nenad N Macura Slobodan S Botuyan Maria Victoria MV Mer Georges G
Biochemistry 20101104 47
Cells have evolved mutagenic bypass mechanisms that prevent stalling of the replication machinery at DNA lesions. This process, translesion DNA synthesis (TLS), involves switching from high-fidelity DNA polymerases to specialized DNA polymerases that replicate through a variety of DNA lesions. In eukaryotes, polymerase switching during TLS is regulated by the DNA damage-triggered monoubiquitylation of PCNA. How the switch operates is unknown, but all TLS polymerases of the so-called Y-family pos ...[more]