Ontology highlight
ABSTRACT:
SUBMITTER: Beer PA
PROVIDER: S-EPMC2995575 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Beer Philip A PA Ortmann Christina A CA Stegelmann Frank F Guglielmelli Paola P Reilly John T JT Larsen Thomas S TS Hasselbalch Hans C HC Vannucchi Alessandro M AM Möller Peter P Döhner Konstanze K Green Anthony R AR
Haematologica 20100907 12
Somatic activating mutations in MPL, the thrombopoietin receptor, occur in the myeloproliferative neoplasms, although virtually nothing is known about their role in evolution to acute myeloid leukemia. In this study, the MPL T487A mutation, identified in de novo acute myeloid leukemia, was not detected in 172 patients with a myeloproliferative neoplasm. In patients with a prior MPL W515L-mutant myeloproliferative neoplasm, leukemic transformation was accompanied by MPL-mutant leukemic blasts, wa ...[more]