Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler DS
PROVIDER: S-EPMC2995822 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Wheeler D S DS Barrick S R SR Grubisha M J MJ Brufsky A M AM Friedman P A PA Romero G G
Oncogene 20100830 1
Although Wnt-Frizzled (Fzd) signaling is critical in the pathophysiology of carcinomas, its role in human breast cancer has been difficult to establish. We show here that the adaptor protein Na(+)/H(+) exchange regulatory factor1 (NHERF1), a protein abundantly expressed in normal mammary epithelium, regulates Wnt signaling, maintaining low levels of β-catenin activation. NHERF1's effects are mediated by direct interactions between one of its PSD-95/drosophila discs large/ZO-1 (PDZ) domains and t ...[more]