Ontology highlight
ABSTRACT:
SUBMITTER: Sparks EE
PROVIDER: S-EPMC2995854 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Sparks Erin E EE Huppert Kari A KA Brown Melanie A MA Washington M Kay MK Huppert Stacey S SS
Hepatology (Baltimore, Md.) 20100401 4
<h4>Unlabelled</h4>Alagille syndrome, a chronic hepatobiliary disease, is characterized by paucity of intrahepatic bile ducts (IHBDs). To determine the impact of Notch signaling specifically on IHBD arborization, we studied the influence of both chronic gain and loss of Notch function on the intact three-dimensional IHBD structure using a series of mutant mouse models and a resin casting method. Impaired Notch signaling in bipotential hepatoblast progenitor cells (BHPCs) dose-dependently decreas ...[more]