Ontology highlight
ABSTRACT:
SUBMITTER: Hudecek M
PROVIDER: S-EPMC2996114 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Hudecek Michael M Schmitt Thomas M TM Baskar Sivasubramanian S Lupo-Stanghellini Maria Teresa MT Nishida Tetsuya T Yamamoto Tori N TN Bleakley Marie M Turtle Cameron J CJ Chang Wen-Chung WC Greisman Harvey A HA Wood Brent B Maloney David G DG Jensen Michael C MC Rader Christoph C Riddell Stanley R SR
Blood 20100811 22
Monoclonal antibodies and T cells modified to express chimeric antigen receptors specific for B-cell lineage surface molecules such as CD20 exert antitumor activity in B-cell malignancies, but deplete normal B cells. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) was identified as a highly expressed gene in B-cell chronic lymphocytic leukemia (B-CLL), but not normal B cells, suggesting it may serve as a tumor-specific target for therapy. We analyzed ROR1-expression in normal nonhemat ...[more]