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A ketogenic diet does not impair rat behavior or long-term potentiation.

ABSTRACT: The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity.

SUBMITTER: Thio LL

PROVIDER: S-EPMC2996229 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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A ketogenic diet does not impair rat behavior or long-term potentiation.

Thio Liu Lin LL Rensing Nicholas N Maloney Susan S Wozniak David F DF Xiong Chengjie C Yamada Kelvin A KA

Epilepsia 20100801 8

The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined ...[more]

PMID: 20132289

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