Ontology highlight
ABSTRACT:
SUBMITTER: Moon EJ
PROVIDER: S-EPMC2996638 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Moon Eui Jung EJ Sonveaux Pierre P Porporato Paolo E PE Danhier Pierre P Gallez Bernard B Batinic-Haberle Ines I Nien Yu-Chih YC Schroeder Thies T Dewhirst Mark W MW
Proceedings of the National Academy of Sciences of the United States of America 20101108 47
Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation have not been elucidated. Here we report that 1 h of HT activates hypoxia-inducible factor-1 (HIF-1) in tumors and its downstream targets, vascular endothelial growth factor (VEGF) and pyruvate dehydrogenase kinase 1 (PDK1). Consistent with HIF-1 activation and up-regulation of its downstream gen ...[more]