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Three-dimensional models of the oligomeric human asialoglycoprotein receptor (ASGP-R).

ABSTRACT: The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal oligomeric form, necessary for it to bind multi-antennary carbohydrate ligands. The ultimate target of the study is to contribute to increasing the knowledge of interactions between the human ASGP-R and carbohydrate ligands, at the molecular level, pertinent to applications in the field of hepatic tissue engineering.

SUBMITTER: Massarelli I

PROVIDER: S-EPMC2996795 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Three-dimensional models of the oligomeric human asialoglycoprotein receptor (ASGP-R).

Massarelli Ilaria I Chiellini Federica F Chiellini Emo E Bianucci Anna Maria AM

International journal of molecular sciences 20101011 10

The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal ol ...[more]

PMID: 21152305

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