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Imaging-genetics applications in child psychiatry.

ABSTRACT: OBJECTIVE:To place imaging-genetics research in the context of child psychiatry. METHOD:A conceptual overview is provided, followed by discussion of specific research examples. RESULTS:Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics. CONCLUSIONS:Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.

SUBMITTER: Pine DS

PROVIDER: S-EPMC2997350 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Imaging-genetics applications in child psychiatry.

Pine Daniel S DS Ernst Monique M Leibenluft Ellen E

Journal of the American Academy of Child and Adolescent Psychiatry 20100409 8

<h4>Objective</h4>To place imaging-genetics research in the context of child psychiatry.<h4>Method</h4>A conceptual overview is provided, followed by discussion of specific research examples.<h4>Results</h4>Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.<h4>Conclusions</h4>Child psychiatry applications of imaging ge ...[more]

PMID: 20643311

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