Ontology highlight
ABSTRACT:
SUBMITTER: Marino D
PROVIDER: S-EPMC2997449 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Marino Daniela D Dabouras Vasilios V Brändli André W AW Detmar Michael M
Journal of vascular research 20101123 3
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived embryoid bodies (EBs). We found that incubation with retinoic acid (RA) and, more potently, with RA in combination with cAMP, induced the expression of the lymphatic competence marker LYVE-1 in the vascular structures of the EBs. This effect was depen ...[more]