Power consequences of linkage disequilibrium variation between populations.
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ABSTRACT:
SUBMITTER: Teo YY
PROVIDER: S-EPMC2997478 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Power consequences of linkage disequilibrium variation between populations.
Teo Yik Y YY Small Kerrin S KS Fry Andrew E AE Wu Yumeng Y Kwiatkowski Dominic P DP Clark Taane G TG
Genetic epidemiology 20090201 2
We quantify the degree to which LD differences exist in the human genome and investigates the consequences that variations in patterns of LD between populations can have on the power of case-control or family-trio association studies. Although only a small proportion of SNPs show significant LD differences (0.8-5%), these can introduce artificial signals of associations and reduce the power to detect true associations in case-control designs, even when meta-analytic approaches are used to accoun ...[more]
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