Ontology highlight
ABSTRACT:
SUBMITTER: Zhou D
PROVIDER: S-EPMC2997593 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Zhou Dongming D Wu Te-Lang TL Lasaro Marcio O MO Latimer Brian P BP Parzych Elizabeth M EM Bian Ang A Li Yan Y Li Hua H Erikson Jan J Xiang Zhiquan Z Ertl Hildegund C J HC
Molecular therapy : the journal of the American Society of Gene Therapy 20100928 12
A universal influenza vaccine, designed to induce broadly cross-reactive immunity against current and future influenza A virus strains, is in critical demand to reduce the need for annual vaccinations with vaccines chosen upon predicting the predominant circulating viral strains, and to ameliorate the threat of cyclically occurring pandemics that have, in the past, killed tens of millions. Here, we describe a vaccine regimen based on sequential immunization with two serologically distinct chimpa ...[more]