Ontology highlight
ABSTRACT:
SUBMITTER: Roberts DN
PROVIDER: S-EPMC299761 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Roberts Douglas N DN Stewart Allen J AJ Huff Jason T JT Cairns Bradley R BR
Proceedings of the National Academy of Sciences of the United States of America 20031121 25
RNA polymerase III (Pol III) transcribes small untranslated RNAs, such as tRNAs. To define the Pol III transcriptome in Saccharomyces cerevisiae, we performed genome-wide chromatin immunoprecipitation using subunits of Pol III, TFIIIB and TFIIIC. Virtually all of the predicted targets of Pol III, as well as several novel candidates, were occupied by Pol III machinery. Interestingly, TATA box-binding protein occupancy was greater at Pol III targets than virtually all Pol II targets, and the highl ...[more]