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Sex-specific parent-of-origin allelic expression in the mouse brain.

ABSTRACT: Genomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamus, sex-specific imprinted genes were mostly found in females, which suggests parental influence over the hypothalamic function of daughters. We show that interleukin-18, a gene linked to diseases with sex-specific prevalence, is subject to complex, regional, and sex-specific parental effects in the brain. Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease.

SUBMITTER: Gregg C

PROVIDER: S-EPMC2997643 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Sex-specific parent-of-origin allelic expression in the mouse brain.

Gregg Christopher C Zhang Jiangwen J Butler James E JE Haig David D Dulac Catherine C

Science (New York, N.Y.) 20100708 5992

Genomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamu ...[more]

PMID: 20616234

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