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Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure.


ABSTRACT:

Background

Vitamin D is a fat-soluble hormone necessary for calcium homeostasis. Recently, studies have demonstrated that vitamin D may be important to the health of the cardiovascular system.

Methods

Adults ? 50 years of age with heart failure were recruited for assessment of serum 25-hydroxyvitamin D (25OHD) concentrations. Cardiopulmonary exercise testing was used to assess functional capacity. Proximal muscle strength was evaluated with a Biodex isokinetic dynamometer [corrected] (Biodex, Shirley, NY), and health status was assessed with the Kansas City Cardiomyopathy Questionnaire. Univariate associations between physical performance and health status measures and 25OHD followed by a linear regression model were used to study associations, adjusting for other potential explanatory variables.

Results

Forty adults 67.8 ± 10.9 years of age (55% women and 57.5% African American) with mean ejection fraction 40% were analyzed (New York Heart Association class II in 70% and class III in 30%). Comorbidities included 77.5% hypertension and 47.5% diabetes. The mean 25OHD concentration was 18.5 ± 9.1 ng/mL, and mean peak Vo?, 14 ± 4 mL/kg/min. In univariate regression analysis, 25OHD was positively associated with peak Vo? (P = .045). Multivariable regression analysis sustained positive association between 25OHD and peak Vo? (P = .044) after adjusting for age, race, and respiratory exchange ratio (adjusted R² = 0.32). Association between proximal muscle strength with the 25OHD concentration was not significant. The Kansas City Cardiomyopathy Questionnaire physical limitation domain score was negatively associated with 25OHD (P = .04) but was not sustained in multivariable analysis.

Conclusions

25-Hydroxyvitamin D may be an important marker or modulator of functional capacity in patients with heart failure. Randomized controlled trials are needed to assess the effect of vitamin D repletion on functional performance.

SUBMITTER: Boxer RS 

PROVIDER: S-EPMC2998064 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Publications

Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure.

Boxer Rebecca S RS   Kenny Anne M AM   Cheruvu Vinay K VK   Vest Marianne M   Fiutem Justin J JJ   Piña Ileana I II  

American heart journal 20101101 5


<h4>Background</h4>Vitamin D is a fat-soluble hormone necessary for calcium homeostasis. Recently, studies have demonstrated that vitamin D may be important to the health of the cardiovascular system.<h4>Methods</h4>Adults ≥ 50 years of age with heart failure were recruited for assessment of serum 25-hydroxyvitamin D (25OHD) concentrations. Cardiopulmonary exercise testing was used to assess functional capacity. Proximal muscle strength was evaluated with a Biodex isokinetic dynamometer [correct  ...[more]

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