Ontology highlight
ABSTRACT:
SUBMITTER: Kaur S
PROVIDER: S-EPMC2998110 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Kaur Sukhbir S Martin-Manso Gema G Pendrak Michael L ML Garfield Susan H SH Isenberg Jeff S JS Roberts David D DD
The Journal of biological chemistry 20101005 50
Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with VEGF and indirectly by engaging several endothelial cell TSP1 receptors. We now describe a more potent mechanism by which TSP1 inhibits VEGF receptor-2 (VEGFR2) activation through engaging its receptor CD47. CD47 ligation is known to inhibit downstream signaling targets of VEGFR2, including endothelial nitric-oxide synthase and soluble guanylate cyclase, but direct effects on VEGFR2 have not been examined. Base ...[more]