Bulk segregation mapping of mutations in closely related strains of mice.
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ABSTRACT:
SUBMITTER: Xia Y
PROVIDER: S-EPMC2998299 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Bulk segregation mapping of mutations in closely related strains of mice.
Xia Yu Y Won Sungyong S Du Xin X Lin Pei P Ross Charles C La Vine Diantha D Wiltshire Sean S Leiva Gabriel G Vidal Silvia M SM Whittle Belinda B Goodnow Christopher C CC Koziol James J Moresco Eva Marie Y EM Beutler Bruce B
Genetics 20101005 4
Phenovariance may be obscured when genetic mapping is performed using highly divergent strains, and closely similar strains are preferred if adequate marker density can be established. We sequenced the C57BL/10J mouse genome using the Applied Biosystems SOLiD platform and here describe a genome-wide panel of informative markers that permits the mapping of mutations induced on the closely related C57BL/6J background by outcrossing to C57BL/10J, and backcrossing or intercrossing. The panel consist ...[more]
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