Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Peng H
PROVIDER: S-EPMC2998423 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells.
Peng Hui H Qi Jing J Dong Zizheng Z Zhang Jian-Ting JT
PloS one 20101207 12
Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays a key role in multidrug resistance and protecting cancer stem cells. ABCG2-knockout had no apparent adverse effect on the development, biochemistry, and life of mice. Thus, ABCG2 is an interesting and promising target for development of chemo-sensitizing agents for better treatment of drug resistant cancers and for eliminating cancer stem cells. Previously, we reported a novel two mode-acting ABCG2 inhibitor, PZ-39, ...[more]
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