Ontology highlight
ABSTRACT:
SUBMITTER: Hee CS
PROVIDER: S-EPMC2998441 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Hee Chee Seng CS Gao Song S Loll Bernhard B Miller Marcia M MM Uchanska-Ziegler Barbara B Daumke Oliver O Ziegler Andreas A
PLoS biology 20101207 12
Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but map outside of the core MHC region. To obtain insights into their function, we determined the structure of the YF1*7.1/β(2)-microgloblin complex by X-ray crystallography at 1.3 Å resolution. It exhibits the architecture typical of classical MHC class I molecules but possesses a hydrophobic binding groove that contains a non-peptidic ligand. This finding prompted us to reconstitute YF1*7.1 also with various ...[more]