Ontology highlight
ABSTRACT:
SUBMITTER: Levy D
PROVIDER: S-EPMC2998712 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Levy Daniel D Ehret Georg B GB Rice Kenneth K Verwoert Germaine C GC Launer Lenore J LJ Dehghan Abbas A Glazer Nicole L NL Morrison Alanna C AC Johnson Andrew D AD Aspelund Thor T Aulchenko Yurii Y Lumley Thomas T Köttgen Anna A Vasan Ramachandran S RS Rivadeneira Fernando F Eiriksdottir Gudny G Guo Xiuqing X Arking Dan E DE Mitchell Gary F GF Mattace-Raso Francesco U S FU Smith Albert V AV Taylor Kent K Scharpf Robert B RB Hwang Shih-Jen SJ Sijbrands Eric J G EJ Bis Joshua J Harris Tamara B TB Ganesh Santhi K SK O'Donnell Christopher J CJ Hofman Albert A Rotter Jerome I JI Coresh Josef J Benjamin Emelia J EJ Uitterlinden André G AG Heiss Gerardo G Fox Caroline S CS Witteman Jacqueline C M JC Boerwinkle Eric E Wang Thomas J TJ Gudnason Vilmundur V Larson Martin G MG Chakravarti Aravinda A Psaty Bruce M BM van Duijn Cornelia M CM
Nature genetics 20090510 6
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; me ...[more]