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Genome-wide association study of blood pressure and hypertension.


ABSTRACT: Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.

SUBMITTER: Levy D 

PROVIDER: S-EPMC2998712 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Genome-wide association study of blood pressure and hypertension.

Levy Daniel D   Ehret Georg B GB   Rice Kenneth K   Verwoert Germaine C GC   Launer Lenore J LJ   Dehghan Abbas A   Glazer Nicole L NL   Morrison Alanna C AC   Johnson Andrew D AD   Aspelund Thor T   Aulchenko Yurii Y   Lumley Thomas T   Köttgen Anna A   Vasan Ramachandran S RS   Rivadeneira Fernando F   Eiriksdottir Gudny G   Guo Xiuqing X   Arking Dan E DE   Mitchell Gary F GF   Mattace-Raso Francesco U S FU   Smith Albert V AV   Taylor Kent K   Scharpf Robert B RB   Hwang Shih-Jen SJ   Sijbrands Eric J G EJ   Bis Joshua J   Harris Tamara B TB   Ganesh Santhi K SK   O'Donnell Christopher J CJ   Hofman Albert A   Rotter Jerome I JI   Coresh Josef J   Benjamin Emelia J EJ   Uitterlinden André G AG   Heiss Gerardo G   Fox Caroline S CS   Witteman Jacqueline C M JC   Boerwinkle Eric E   Wang Thomas J TJ   Gudnason Vilmundur V   Larson Martin G MG   Chakravarti Aravinda A   Psaty Bruce M BM   van Duijn Cornelia M CM  

Nature genetics 20090510 6


Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; me  ...[more]

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