Ontology highlight
ABSTRACT:
SUBMITTER: Matsuyama A
PROVIDER: S-EPMC299872 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Matsuyama Ayumi A Shiraishi Takeshi T Trapasso Francesco F Kuroki Tamotsu T Alder Hansjuerg H Mori Masaki M Huebner Kay K Croce Carlo M CM
Proceedings of the National Academy of Sciences of the United States of America 20031120 25
Common fragile sites are regions that show elevated susceptibility to DNA damage, leading to alterations that can contribute to cancer development. FRA3B, located at chromosome region 3p14.2, is the most frequently expressed human common fragile site, and allelic losses at FRA3B have been observed in many types of cancer. The FHIT gene, encompassing the FRA3B region, is a tumor-suppressor gene. To identify the features of FHIT/FRA3B that might contribute to fragility, sequences of the human FHIT ...[more]