Ontology highlight
ABSTRACT:
SUBMITTER: Terpening C
PROVIDER: S-EPMC2998935 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Clinical Medicine Insights. Cardiology 20101201
The thienopyridine antiplatelet agent clopidogrel is an effective drug for the prevention of vascular events. However, data has accumulated over time to suggest it is prone to significant interpatient variability. While there are several factors that contribute to this, one of the most important is variability in forming the active metabolite necessary for clopidogrel function. Several enzymes are involved in formation of this metabolite, and two, CYP2C19 and P-glycoprotein, appear to have allel ...[more]