Ontology highlight
ABSTRACT:
SUBMITTER: Seth A
PROVIDER: S-EPMC2998996 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Seth Anandita A Machingo Quentin J QJ Fritz Andreas A Shur Barry D BD
Developmental dynamics : an official publication of the American Association of Anatomists 20101201 12
Complex carbohydrates represent one of the most polymorphic classes of macromolecules, but their functions during embryonic development remain poorly defined. Herein, we show that knockdown of FucT8, the fucosyltransferase responsible for adding an α1,6 fucosyl residue to the core region of N-linked oligosaccharides, results in defective midline patterning during zebrafish development. Reduced FucT8 expression leads to mild cyclopia, small forebrains, U-shaped somites, among other midline patter ...[more]