A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.
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ABSTRACT:
SUBMITTER: Bicker KL
PROVIDER: S-EPMC2999663 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
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A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1.
Bicker Kevin L KL Obianyo Obiamaka O Rust Heather L HL Thompson Paul R PR
Molecular bioSystems 20100706 1
The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states. Here we report the design, synthesis, and screening of a combinatorial peptide library used to characterize the substrate specificity of PRMT1. The information gained from this approach was used to develop a PRMT1 inhibitor with enhanced selectivity. ...[more]
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