Ontology highlight
ABSTRACT:
SUBMITTER: Deleris A
PROVIDER: S-EPMC2999860 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Deleris Angelique A Greenberg Maxim V C MV Ausin Israel I Law Rona W Y RW Moissiard Guillaume G Schubert Daniel D Jacobsen Steven E SE
EMBO reports 20101105 12
Histone demethylases-both lysine-specific demethylase 1 (LSD1) and Jumonji-C (JmjC) domain-containing proteins-are broadly implicated in the regulation of chromatin-dependent processes. In Arabidopsis thaliana, histone marks directly affect DNA methylation, and mutations in LSD1 homologues show reduced DNA methylation at some loci. We screened transfer DNA mutations in genes encoding JmjC domains for defects in DNA methylation. Mutations in jmj14 result in reduced DNA methylation in non-CG conte ...[more]