Cellular reactive oxygen species inhibit MPYS induction of IFN?.
Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC3000824 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Cellular reactive oxygen species inhibit MPYS induction of IFNβ.
Jin Lei L Lenz Laurel L LL Cambier John C JC
PloS one 20101210 12
Many inflammatory diseases, as well as infections, are accompanied by elevation in cellular levels of Reactive Oxygen Species (ROS). Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFNβ expression during infection, is a ROS sensor. ROS induce intermolecular disulfide bonds formation in MPYS homodimer and inhibit MPYS IFNβ stimulatory activity. Cys-64, -148, -292, -309 and the potential C₈₈xxC₉₁ redox motif in MPYS are indispensable for IFNβ stimulation a ...[more]
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