Ontology highlight
ABSTRACT:
SUBMITTER: Lokareddy RK
PROVIDER: S-EPMC3000978 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Lokareddy Ravi Kumar RK Lunelli Michele M Eilers Björn B Wolter Vivien V Kolbe Michael M
The Journal of biological chemistry 20101011 51
Type III secretion systems (TTSSs) utilized by enteropathogenic bacteria require the presence of small, acidic virulence-associated chaperones for effective host cell infection. We adopted a combination of biochemical and cellular techniques to define the chaperone binding domains (CBDs) in the translocators IpaB and IpaC associated with the chaperone IpgC from Shigella flexneri. We identified a novel CBD in IpaB and furthermore precisely mapped the boundaries of the CBDs in both translocator pr ...[more]