Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Godinez V
PROVIDER: S-EPMC3001094 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Gomez-Godinez Veronica V Wu Tao T Sherman Adria J AJ Lee Christopher S CS Liaw Lih-Huei LH Zhongsheng You Y Yokomori Kyoko K Berns Michael W MW
Nucleic acids research 20101004 22
In this study the femtosecond near-IR and nanosecond green lasers are used to induce alterations in mitotic chromosomes. The subsequent double-strand break responses are studied. We show that both lasers are capable of creating comparable chromosomal alterations and that a phase paling observed within 1-2 s of laser exposure is associated with an alteration of chromatin as confirmed by serial section electron microscopy, DAPI, γH2AX and phospho-H3 staining. Additionally, the accumulation of dark ...[more]