Ontology highlight
ABSTRACT:
SUBMITTER: Choi YH
PROVIDER: S-EPMC3001494 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Choi Yoon Ha YH Park Choon-Ho CH Kim Wanil W Ling Hua H Kang Aram A Chang Matthew Wook MW Im Sun-Kyoung SK Jeong Hyun-Woo HW Kong Young-Yun YY Kim Kyong-Tai KT
PloS one 20101213 12
Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility. Here we describe that VRK1 is essential for the maintenance of spermatogonial stem cells. To determine whether VRK1 plays a role in these cells, we assessed the population size of undifferentiated spermatogonia. Flow cytometry analyses showed that the number of undifferentiated spermatogonia was markedly reduced in VR ...[more]