Ontology highlight
ABSTRACT:
SUBMITTER: Shukla A
PROVIDER: S-EPMC3001639 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Shukla Anshuman A Pallen Mark M Anthony Mark M White Scott A SA
Acta crystallographica. Section F, Structural biology and crystallization communications 20101027 Pt 11
ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphy ...[more]