Ontology highlight
ABSTRACT:
SUBMITTER: Kovarova Z
PROVIDER: S-EPMC3001646 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Kovářová Zuzana Z Chmelař Jindřich J Sanda Miloslav M Brynda Jiří J Mareš Michael M Rezáčová Pavlína P
Acta crystallographica. Section F, Structural biology and crystallization communications 20101028 Pt 11
IRS-2 from the hard tick Ixodes ricinus belongs to the serpin family of protease inhibitors. It is produced in the salivary glands of the tick and its anti-inflammatory activity suggests that it plays a role in parasite-host interaction. Recombinant IRS-2 prepared by heterologous expression in a bacterial system was crystallized using the hanging-drop vapour-diffusion method. The crystals belonged to the primitive tetragonal space group P4(3) and diffracted to 1.8 Å resolution. Mass-spectrometri ...[more]