Hepatitis C virus replication and potential targets for direct-acting agents.
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ABSTRACT:
SUBMITTER: O'Leary JG
PROVIDER: S-EPMC3002563 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Hepatitis C virus replication and potential targets for direct-acting agents.
O'Leary Jacqueline G JG Davis Gary L GL
Therapeutic advances in gastroenterology 20100101 1
We finally stand at the brink of novel, oral, direct-acting antivirals for the treatment of hepatitis C virus (HCV) infection. Basic science research has lead to a greater understanding of the viral life cycle and identified numerous potential targets for therapy. Early compounds were plagued by inconsistent in vivo activity and side effects that led to discontinuation of investigational efforts. However, several agents have now progressed to phase 2 human studies and two protease inhibitors hav ...[more]
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