Ontology highlight
ABSTRACT:
SUBMITTER: Mitea C
PROVIDER: S-EPMC3002971 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Mitea Cristina C Salentijn Elma M J EM van Veelen Peter P Goryunova Svetlana V SV van der Meer Ingrid M IM van den Broeck Hetty C HC Mujico Jorge R JR Montserrat Veronica V Gilissen Luud J W J LJ Drijfhout Jan Wouter JW Dekking Liesbeth L Koning Frits F Smulders Marinus J M MJ
PloS one 20101216 12
Celiac disease is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins, including the α-gliadins. It has been shown that α-gliadins harbor several major epitopes involved in the disease pathogenesis. A major step towards elimination of gluten toxicity for celiac disease patients would thus be the elimination of such epitopes from α-gliadins. We have analyzed over 3,000 expressed α-gliadin sequences from 11 bread wheat cultivars to determine wheth ...[more]