Ontology highlight
ABSTRACT:
SUBMITTER: Lindskog M
PROVIDER: S-EPMC3003060 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Lindskog Maria M Li Li L Groth Rachel D RD Poburko Damon D Thiagarajan Tara C TC Han Xue X Tsien Richard W RW
Proceedings of the National Academy of Sciences of the United States of America 20101123 50
Prolonged blockade of AMPA-type glutamate receptors in hippocampal neuron cultures leads to homeostatic enhancements of pre- and postsynaptic function that appear correlated at individual synapses, suggesting some form of transsynaptic coordination. The respective modifications are important for overall synaptic strength but their interrelationship, dynamics, and molecular underpinnings are unclear. Here we demonstrate that adaptation begins postsynaptically but is ultimately communicated to pre ...[more]