Ontology highlight
ABSTRACT:
SUBMITTER: Maret D
PROVIDER: S-EPMC3003141 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Maret Deborah D Gruzglin Eugenia E Sadr Mohamad Seyed MS Siu Vincent V Shan Weisong W Koch Alexander W AW Seidah Nabil G NG Del Maestro Rolando F RF Colman David R DR
Neoplasia (New York, N.Y.) 20101201 12
The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis. However, NCAD-mediated adhesion is a robust phenomenon and therefore seems to be inconsistent with the "release" from intercellular adhesion required for invasion. We show that in the most invasive melanoma and brain tumor cells, altered posttranslational processing results in abundant nonadhesive precursor N-cadherin (proNCAD) at the cell surface, although total NCAD levels remain ...[more]