Ontology highlight
ABSTRACT:
SUBMITTER: Buchanan KA
PROVIDER: S-EPMC3003154 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Buchanan Katherine A KA Petrovic Milos M MM Chamberlain Sophie E L SE Marrion Neil V NV Mellor Jack R JR
Neuron 20101201 5
Muscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor subtype involved and the critical intracellular signaling pathways engaged have remained controversial. Here, we show that the recently discovered highly selective allosteric M(1) receptor agonist 77-LH-28-1 facilitates long-term potentiation (LTP) induced by theta burst stimulation at Schaffer collateral synapses in the hippocampus. Similarly ...[more]