Ontology highlight
ABSTRACT:
SUBMITTER: Fox RM
PROVIDER: S-EPMC3003312 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Fox Rebecca M RM Hanlon Caitlin D CD Andrew Deborah J DJ
The Journal of cell biology 20101101 3
Secretion occurs in all cells, with relatively low levels in most cells and extremely high levels in specialized secretory cells, such as those of the pancreas, salivary, and mammary glands. How secretory capacity is selectively up-regulated in specialized secretory cells is unknown. Here, we find that the CrebA/Creb3-like family of bZip transcription factors functions to up-regulate expression of both the general protein machinery required in all cells for secretion and of cell type-specific se ...[more]