Ontology highlight
ABSTRACT:
SUBMITTER: Fourniol FJ
PROVIDER: S-EPMC3003314 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Fourniol Franck J FJ Sindelar Charles V CV Amigues Béatrice B Clare Daniel K DK Thomas Geraint G Perderiset Mylène M Francis Fiona F Houdusse Anne A Moores Carolyn A CA
The Journal of cell biology 20101025 3
Microtubule-associated proteins (MAPs) are essential for regulating and organizing cellular microtubules (MTs). However, our mechanistic understanding of MAP function is limited by a lack of detailed structural information. Using cryo-electron microscopy and single particle algorithms, we solved the 8 Å structure of doublecortin (DCX)-stabilized MTs. Because of DCX's unusual ability to specifically nucleate and stabilize 13-protofilament MTs, our reconstruction provides unprecedented insight int ...[more]