Endogenous ligands for nuclear receptors: digging deeper.
Ontology highlight
ABSTRACT:
SUBMITTER: Schupp M
PROVIDER: S-EPMC3003339 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Endogenous ligands for nuclear receptors: digging deeper.
Schupp Michael M Lazar Mitchell A MA
The Journal of biological chemistry 20101018 52
Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs through the identification of their endogenous ligands is a key element for our understanding of their biology. In this minireview, we give an update on recent progress in regard to endogenous ligands for a cluster of NRs with high sequence homology, namely peroxisome proliferator-activated receptors α and γ, Rev-erbα ...[more]
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