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ABSTRACT:
SUBMITTER: Briffotaux J
PROVIDER: S-EPMC3003400 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Briffotaux Julien J Kobryn Kerri K
The Journal of biological chemistry 20101014 52
Spirochetes of the genus Borrelia include the tick-transmitted causative agents of Lyme disease and relapsing fever. They possess unusual genomes composed mainly of linear replicons terminated by closed DNA hairpins. Hairpin telomeres are formed from inverted repeat replicated telomere junctions (rTels) by the telomere resolvase ResT. ResT uses a reaction mechanism similar to that of the type IB topoisomerases and tyrosine recombinases. ResT can catalyze three distinct reactions: telomere resolu ...[more]