Protein folds and protein folding.

ABSTRACT: The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds). Although similar topologies may arise by convergent evolution, the similarity of their respective folding pathways is unknown. The discovery and the characterization of the majority of protein folds will be followed by a similar enumeration of available protein folding pathways. Consequently, understanding the intricacies of structural domains is necessary to understanding their collective folding pathways. We review the current state of the art in the field of protein domain classification and discuss met

SUBMITTER: Schaeffer RD 

PROVIDER: S-EPMC3003448 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature