Ontology highlight
ABSTRACT:
SUBMITTER: Johnston PB
PROVIDER: S-EPMC3003620 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Johnston Patrick B PB Yuan RuiRong R Cavalli Franco F Witzig Thomas E TE
Journal of hematology & oncology 20101123
Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian target of rapamycin (mTOR) pathways are examples of pathological mechanisms that are being targeted in drug ...[more]