Ontology highlight
ABSTRACT:
SUBMITTER: Haldar SM
PROVIDER: S-EPMC3003709 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Haldar Saptarsi M SM Lu Yuan Y Jeyaraj Darwin D Kawanami Daiji D Cui Yingjie Y Eapen Sam J SJ Hao Caili C Li Yan Y Doughman Yong-Qiu YQ Watanabe Michiko M Shimizu Koichi K Kuivaniemi Helena H Sadoshima Junichi J Margulies Kenneth B KB Cappola Thomas P TP Jain Mukesh K MK
Science translational medicine 20100401 26
Current therapies for diseases of heart muscle (cardiomyopathy) and aorta (aortopathy) include inhibitors of the renin-angiotensin system, beta-adrenergic antagonists, and the statin class of cholesterol-lowering agents. These therapies have limited efficacy, as adverse cardiovascular events continue to occur with some frequency in patients taking these drugs. Although cardiomyopathy and aortopathy can coexist in a number of conditions (for example, Marfan's syndrome, acromegaly, pregnancy, and ...[more]