Ontology highlight
ABSTRACT:
SUBMITTER: Federico M
PROVIDER: S-EPMC3004414 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Federico Mario M Bagella Luigi L
Journal of biomedicine & biotechnology 20101206
The human genome is epigenetically organized through a series of modifications to the histone proteins that interact with the DNA. In cancer, many of the proteins that regulate these modifications can be altered in both function and expression. One example of this is the family of histone deacetylases (HDACs), which as their name implies remove acetyl groups from the histone proteins, allowing for more condensed nucleosomal structure. HDACs have increased expression in cancer and are also believ ...[more]