Mitochondrial dysfunction in the elderly: possible role in insulin resistance.
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ABSTRACT:
SUBMITTER: Petersen KF
PROVIDER: S-EPMC3004429 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Publications
Mitochondrial dysfunction in the elderly: possible role in insulin resistance.
Petersen Kitt Falk KF Befroy Douglas D Dufour Sylvie S Dziura James J Ariyan Charlotte C Rothman Douglas L DL DiPietro Loretta L Cline Gary W GW Shulman Gerald I GI
Science (New York, N.Y.) 20030501 5622
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly. To investigate how insulin resistance arises, we studied healthy, lean, elderly and young participants matched for lean body mass and fat mass. Elderly study participants were markedly insulin-resistant as compared with young controls, and this resistance was attributable to reduced insulin-stimulated muscle glucose metabolism. These changes were associated with increased fat accumulation in muscle and li ...[more]
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