Ontology highlight
ABSTRACT:
SUBMITTER: Weiss JN
PROVIDER: S-EPMC3005298 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Weiss James N JN Garfinkel Alan A Karagueuzian Hrayr S HS Chen Peng-Sheng PS Qu Zhilin Z
Heart rhythm 20100922 12
Early afterdepolarizations (EADs) are an important cause of lethal ventricular arrhythmias in long QT syndromes and heart failure, but the mechanisms by which EADs at the cellular scale cause arrhythmias such as polymorphic ventricular tachycardia (PVT) and torsades de pointes (TdP) at the tissue scale are not well understood. Here we summarize recent progress in this area, discussing (1) the ionic basis of EADs, (2) evidence that deterministic chaos underlies the irregular behavior of EADs, (3) ...[more]